This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
Gene Ontology
The Gene Ontology (GO) consortium seeks to assemble bioinformatic information to provide comprehensive annotation of orthologous gene in the wide variety of model organisms. The GO project categorizes the functions of gene product in the cell based on biological process, cellular component and molecular function.
AmiGOUsing AmiGO website, protein associations for the HEXA gene in Homo sapiens are found and shown as follows:
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Biological Processes
Cellular component
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Biological Processes
Molecular function
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A search of HEXA on AmiGO yielded a large network of functions and associations with other genes and proteins. The full association tree of HEXA Gene Ontology Interactions in Homo sapiens can be shown in a graphical view. Click at this file to view the tree and click here to link out to the interactive website
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GO id:0004563
Name : beta-N-acetylhexosaminidase activity
Ontology: Molecular Function
Definition: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Name : beta-N-acetylhexosaminidase activity
Ontology: Molecular Function
Definition: Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.
Analysis
GOA only gave 1 biological process and 4 molecular functions terms. Besides, the info given by GOA was less detailed. Thus, I preferred to use AmiGO to look for gene ontology. Based on the results from AmiGO and GOA, I found out that HEXA protein has important roles in ganglioside catabolic process (biological process) and beta-N-acetylhexosaminidase activity (molecular function).
References
1. AMIGO
2. The Gene Ontology Consortium. (2008). The gene ontology project in 2008. Nucleic Acids Research, 36(Sp. 1), D440-D444. doi: 10.1093/nar/gkm883
3. Barrell D., Dimmer E., Huntley R.P., Binns D., O'Donovan C., Apweiler R. (2009). The GOA database in 2009--an integrated Gene Ontology Annotation resource. Nucleic Acids Research, 37: D396-D403. doi:10.1093/nar/gkn803
4. GOA
2. The Gene Ontology Consortium. (2008). The gene ontology project in 2008. Nucleic Acids Research, 36(Sp. 1), D440-D444. doi: 10.1093/nar/gkm883
3. Barrell D., Dimmer E., Huntley R.P., Binns D., O'Donovan C., Apweiler R. (2009). The GOA database in 2009--an integrated Gene Ontology Annotation resource. Nucleic Acids Research, 37: D396-D403. doi:10.1093/nar/gkn803
4. GOA