This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
Hexa Protein Phylogeny
Analysis
These three phylogenetics tree, which are generated from different database, shows the relatedness of the Hexa protein in the human (Homo sapiens), Chimpanzee (Pan troglodytes), dog (Canis lupus familiaris), cattle (Bos taurus), mouse (Mus musculus), rat (Rattus norvegicus), chicken (Gallus gallus), zebrafish (Danio rerio), and small flowering plant (Arabidopsis thaliana). The ClustalW2, Phylogeny.fr and TreeTop database give relatively similar results on the evolutionary relatedness of Hexa protein. Notably, human Hexa protein is most closely related to its homolog in the chimpanzee. On the other hand, the placement of Bos taurus and Canis lupus familiaris from TreeTop (figure 3) is quite different from the other two phylogenetic trees (Figure 1 & 2). This could be due to the use of different algorithm that each program applies to calculate the distance between branch points.
References
1. Liu, G. , & Gao, S. (2009). Molecular cloning, sequence identification and tissue expression profile of three novel sheep (ovis aries) genes - bckdha, naga and hexa. Biological Research, 42(1), 69-77. doi: 10.4067/S0716-97602009000100007
2. ClustalW2
3. Phylogeny.fr
4. TreeTop
2. ClustalW2
3. Phylogeny.fr
4. TreeTop