This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
HEXA Interaction Network
A search on String generated an interaction network showing proteins that may interact with HEXA protein.
predicted_functional_partners.docx | |
File Size: | 15 kb |
File Type: | docx |
Analysis
There are three forms of β-hexoaminidase which are hexoaminidase A, hexoamidase B and hexoaminidase S. Hex A is a heterodimer of α and β subunits. HEXA gene encodes the α-subunit of the lysosomal enzyme β-N-acetylhexoaminidase A (Hex A). Mutations in the the α-subunit are associated with TSD. The related enzyme, Hex B, comprises two beta-subunits.
In the brain and other tissues, beta-hexosaminidase A degrades GM2 ganglioside. GM2 ganglioside activator binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta hexosaminidase A.
In the brain and other tissues, beta-hexosaminidase A degrades GM2 ganglioside. GM2 ganglioside activator binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta hexosaminidase A.
References
1. String
2. Chavany, C. , & Jendoubi, M. (1998). Biology and potential strategies for the treatment of gm2 gangliosidoses. Mol Med Today, 4(4), 158-165.
2. Chavany, C. , & Jendoubi, M. (1998). Biology and potential strategies for the treatment of gm2 gangliosidoses. Mol Med Today, 4(4), 158-165.