This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
HEXA protein subcellular localization
The localization of HEXA is predicted by the following databases:
LOCATE database classified HEXA protein as secreted protein.
Predicted location: lysosome
Hum-mPloc database
Predicted location: lysosome
TargetP database
Predicted location: secretory pathway
LOCATE database classified HEXA protein as secreted protein.
Predicted location: lysosome
Hum-mPloc database
Predicted location: lysosome
TargetP database
Predicted location: secretory pathway
Analysis
According to Uniprot database, HEXA protein is responsible for the degradation of GM2 gangliosides in the brain. The GM2 gangliosides are accumulated in the neuronal cells in the absent of HEXA activity. Thus, it is reasonable that HEXA protein is located at lysosome as secreted protein.